As a reader I always look for quality. But I see how that can change if you’re a writer. The point is that there will always be people ready to appreciate a very overused storyline as well as a creative and innovative one.
If the story has clichés, there’s people who’ll read it for the clichés. Probably not the best story out there, but one with an audience.
If the story is unique and well done, it’ll eventually gather a dedicated fandom too. If it’s advertised, it’ll just happen slowly.
The point is that recurring elements are comforting to find, while new ones trigger curiosity. Both of which have their own power. So, do what you think you’ll enjoy writing most and what will make you proud. If well done, readers will come either way as a consequence.